Long Now Foundation's Seminars
Really great set of 1-1:30 hour lectures on many topics but mostly about long term thinking and experiences.
http://longnow.org/seminars/podcast/
Science for the People
Topical science interviews
http://www.scienceforthepeople.ca/
The British History Podcast
Great presentation of UK history from the beginning
http://thebritishhistorypodcast.com/
The D6 Generation
Boardgames and more.
http://www.thed6generation.com/
Meeples & Miniatures
Military, fantasy, and science fiction miniature wargames
http://meeples.wordpress.com/
The Memory Palace
Forgotten people doing big and small things
http://thememorypalace.us/
Sawbones
History of medicine
http://www.maximumfun.org/shows/sawbones
You are not so smart
The qualities of thinking and our flaws
http://youarenotsosmart.com/
Futility Closet
Trivia and oddities from the past
http://www.futilitycloset.com/